Uridine is a naturally occurring compound is often taken in combination with Choline. It has been studied to benefit brain development, focus and memory.
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For people seeking further memory and learning benefits, studies point to Uridine being a sustainable brain development supplement that stacks incredibly well with Choline.
Uridine is a naturally occurring compound found in broccoli, tomatoes and barley. A growing number of studies point to it being used in brain-development by building neurons and helping them build connections to each other. As a result of these processes, Uridine has been observed as a memory enhancer.
As well as its role in brain development, Uridine has the potential to benefit focus and concentration because it encourages the release of the motivation neurotransmitter Dopamine.
Uridine is a great supplement to take every day, and MIT research suggests that it combines very well with a Choline supplement: Alpha GPC or CDP Choline.
Dietary sources: Uridine can be found in broccoli, tomatoes and barley.
Who should take it: Everybody can benefit from Uridine's role in brain development, especially those already taking a Choline supplement. People needing motivation to work can also see benefits from its role in Dopamine release.
Quality of studies: Research is mostly limited to animals but with positive results. Just under 2,000 publications in the last 5 years on Pubmed.
Time to effect: Increased motivation (from dopamine release) may be felt with an hour, however memory benefits are built over time - at least several weeks.
Combine it with:Choline and DHA (found omega-3 capsules)
Don't combine it with: High intake of Caffeine can cause irritability.
Recommended dose: 500mg-1000mg per day.
Cycling: Not required.
Studies on Brain Development:
A growing number of studies point to Uridine being a beneficial brain-development compound.
An animal study found that Uridine increased the release of the learning neurotransmitter Acetylcholine in the stratium area of the brain, which plays a key role in "reward motivation behaviour". (Massachusetts Institute of Technology - link to study)
Uridine increases the production of phosphatidylcholine, which is used to build and repair the outer layer of neurons called their cell membranes. (Massachusetts Institute of Technology - link to study)
Uridine promotes brain plasticity, which is the ability of our brains to change and optimise its structure by forming new connections between neurons. (Semmelweis University - link to study)
A 6 week animal study at MIT found that 330mg/day of Uridine significantly increased neurite outgrowth (by as much as 121%). Neurites and dendrites are the long "tentacles" that connect neurons (brain-cells) to each other. (Massachusetts Institute of Technology - link to study)
Another 2008 study at MIT saw significant dendrite growth for neurons located in the hippocampus region of the brain - the memory center. (Massachusetts Institute of Technology - link to study)
A human study of 26 elderly people concluded that Uridine caused a "significant improvement in memory abilities (recall, recognition, and spatial short term)" (Tel-Aviv Sourasky Medical Center - link to study)
A human study of supplementing Uridine with Choline saw improvements in verbal and logical memory (Semmelweis University and the Hungarian Academy of Sciences - link to study)
An animal study found that Uridine improved memory and learning. (Semmelweis University and the Hungarian Academy of Sciences - link to study)
An animal study combining Uridine, Choline and DHA (found in omega 3) resulted in improved memory and learning, increased neurite outgrowth and increased Acetylcholine release. (Massachusetts Institute of Technology - link to study)
Uridine is seen to "amplify" the functionality of Acetylcholine, the learning neurotransmitter that is used by neurons to communicate with each other. (Massachusetts Institute of Technology - link to study)
Uridine has been studied to enhance focus and concentration by encouraging the release of the motivation-to-work neurotransmitter Dopamine.
An animal study showed that Uridine supplementation increased the release of the motivation neurotransmitter dopamine. (Massachusetts Institute of Technology - link to study)
Brain scans showed that people with higher dopamine levels tend to be "go-getters" and work harder. People with lower dopamine levels tend to be "slackers". (Vanderbilt University - link to study)
Uridine is also seen to "modulate" the release of dopamine, strengthening the receptors when there is more dopamine being released to avoid getting desensitised. (Rutgers University - link to study)
Instructions on How to Take Uridine:
On its own:
500mg-1000mg of Uridine per day has been demonstrated to have cognitive-enhancing effects.
Combined with a Choline supplement:
If you combine it with a Choline source (Alpha GPC or CDP Choline), it's a good idea to match the dosage. e.g. 500mg CDP Choline + 500mg Uridine.
Knowing your limits:
Too much Uridine can cause diarrhoea and induce fevers. (Semmelweis University - link to study)
Don't drink too much coffee:
Some users report that drinking high amounts of coffee with Uridine can cause irritability.
What combines well with Uridine?
1. A Choline supplement (Alpha GPC or CDP Choline) - Studies at MIT revealed that Uridine synergises extremely well with Choline by increasing the production of neuron cell membranes (link to study). Other research has shown that the combination improves spatial awareness and selective attention (link to study). We sell both Alpha GPC and CDP Choline.
2. DHA (found in Omega-3) - Similar to Choline, Uridine has been studied to synergise well with DHA for memory and learning benefits. We don't sell this yet, but we will soon. (MIT - link to study)
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