Supplement of the Month - Citicoline

December 01, 2016

Supplement of the Month - Citicoline

December can often times be a month that tests the sheer limit of our memory. There are so many things to remember to make the holidays go by smoothly that sometimes you’d wish you could have a little help in the memory department.

As a result we have chosen Citicoline as Supplement of the month! This month all Citicoline tablets are 40% off. 

Here are some benefits of the product:

It can help you solve mental tasks quicker - With higher choline levels, expect to solve mental tasks quicker and say goodbye to any form of brain fog!

Improved memory recall - Recall stored memories faster with greater neuroactivity and communication within the brain.

Focus - Boost your focus levels and mental endurance when presented with long or difficult tasks.

Mental reactions - Choline has been seen to boost the formation of synapses and connections between neurons within your brain... Allowing you to react faster to situations and improve your ability to learn new segments of information.

Below is some more detail on the science behind it... 

In order to boost our memories we need to develop a good understanding of what memories actually are. Most of our memories start of as a rapid conversion of an electrical to a chemical signal, which originates in an area of the brain called the hippocampus.

Within the hippocampus there is an area called CA1 and this area has a high concentration of glutamatergic NMDA receptors and cholinergic M1 receptors. This is where a process called long term potentiation (LTP) occurs, it happens when the neurotransmitter glutamate binds to and activates the NMDA receptor, this causes the receptor to open and allows calcium ions to flow in which causes an extensive signalling cascade within the neuron associated with this receptor. Collectively this process is known as neuroplasticity, and allows us to form stronger connections between certain neurons. Very simply speaking, our memories are in essence physical changes in brain wiring brought on by NMDA receptor induced neuroplasticity.

It now seems like it would be fairly simple to just activate NMDA receptors in the CA1 in order to boost memory, but extensive research has show that this is much harder and more problematic than it seems. Instead we have to work via a work around and take advantage of the M1 receptors in this same area. By activating these receptors, we can increase the likelihood of the NMDA receptor becoming activated. M1 receptors are activated mainly by the neurotransmitter acetylcholine. This neurotransmitter is produced from choline, which is an amino acid that is present in our diets. This choline is pulled into acetylcholine neurons where it is rapidly converted to acetylcholine. A way in which to enhance this process is to supplement with Citicoline, which is a highly bioavailable form of choline that much more readily reaches the brain than dietary sources of choline. By spiking acetylcholine levels in the brain with Citicoline we can make sure that the M1 receptor becomes activated which significantly lowers the threshold for LTP to take place, this effect will ultimately boost memory. However, Citicoline’s role in memory enhancement doesn’t stop there, because apart from being an acetylcholine precursor, it is also a great precursor for Uridine, which is a nutrient that is also present in our diets and plays a critical role in many brain functions. The biggest advantage of uridine in terms of memory is that it aids in the process of neuroplasticity. Thus not only are we increasing neuroplasticity via LTP with Citicoline supplementation, we are bolstering the neuroplasticity induced by LTP, which could potentially enhance our memory significantly.  

References

Ishibashi, M., Yamazaki, Y., Miledi, R., & Sumikawa, K. (2014). Nicotinic and

muscarinic agonists and acetylcholinesterase inhibitors stimulate a common pathway to enhance GluN2B-NMDAR responses. Proceedings of the National Academy of Sciences, 111(34), 12538-12543




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