What is Pramiracetam?
Pramiracetam is part of a family of compounds called the racetams. All racetams are pyrrolidone derivatives, the first of which was piracetam. Corneliu E. Giurgea first synthesized Piracetam in 19641, he later coined the term ‘nootropic’ in 19722. All racetams share a 2-pyrrolidone core structure, modifications of this core structure result in changes in solubility, absorption, potency and pharmacological action.
For example Piracetam is water-soluble and requires fairly high doses whereas Pramiracetam is fat soluble and requires much smaller doses. In addition to this, Pramiracetam exhibits unique pharmacological actions, which are not achieved by Piracetam.
What are Pramiracetams applications?
Anecdotally Pramiracetam seems to be very effective at increasing an individual’s focus and increasing logical thinking. However this does come at the expense of making the individual feel emotionally detached. This can be very useful when you’re studying for a difficult exam and need to be fully emerged in the material, but is a major hindrance in any social situation. Due to this it is best to take Pramiracetam acutely when you have a difficult study session opposed to taking it on a daily basis.
The exact mechanism of action for Pramiracetam is not entirely known yet however it is known that Pramiracetam increases high affinity choline uptake (HACU) in the hippocampus3. HACU is the processes by which choline is taken up by cells and is and is the rate-limiting step in acetylcholine production. Increasing HACU results in greater acetylcholine production, which is very important in terms of memory and learning since acetylcholine is highly involved with these processes. The hippocampus is one of the main brain regions involved in memory and learning and thus an increase in HACU in the hippocampus can greatly enhance memory and learning.
How to take
As discussed earlier, Pramiracetam is best taken acutely when studying for a difficult exam. For this purpose an individual should take between 250-1,200 mg during the day, preferably split into two or three separate doses. Since Pramiracetam is fat soluble it is best to take it along side a fat containing meal. It is recommended to take Pramiracetam in a tablet form rather than in a powder form because it has a very bad taste. You can purchase Pramiracetam tablets in our store here.
Written by Emiel Bakker on behalf of Focus Supplements
- Giurgea CE, Greindl MG, Preat S (1983). "Nootropic drugs and aging".Acta Psychiatr Belg83 (4): 349–58.
- Gazzaniga, Michael S. (2006). The Ethical Brain: The Science of Our Moral Dilemmas (P.S.). New York, N.Y: Harper Perennial. p. 184.
- Pugsley, T., Shih, Y., Coughenour, L., & Stewart, S. (1983). Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent. Drug Dev. Res. Drug Development Research, 3, 407-420.
HIIT Exercise and Its Effects on the Body and Brain
Like speed dating, "high intensity interval training" (HIIT) is an innovation that's become popular in the twenty-fir...
An Introduction to Nootropics
So you're interested in the world of Nootropics, huh? Perhaps you want to get more work done... Or you want to "recal...
Get Caffeine + L-Theanine at 40% Off (June Supplement of the Month)
You're probably a coffee drinker. It's great for concentration, improving your attention, and giving you a "kick" to ...
- 5HTP - High Strength
- Alpha GPC
- Alpha GPC + Uridine
- Alpha Lipoic Acid
- Caffeine + L-Theanine
- CDP Choline
- CDP Choline + Uridine
- Choline Bundle
- Energy Boost - Pre Workout
- Huperzine A
- Hyaluronic Acid
- LongJack Tongkat Ali
- Rhodiola Rosea
- Uridine Monophosphate