The Most Potent Racetam Derivative by Volume, Noopept
Every month at Focus Supplements we choose one of our popular supplements to feature as supplement of the month and offer a tremendous 50% discount. This month’s choice is... Noopept 30mg tablets.
Noopept is a relatively new chemical cousin of the old standby in any cognitive enhancer’s nootropic toolkit, the well-studied and reliable classic nootropic, Piracetam. Like Piracetam, it is a mild, psychostimulatory agent and cholinergic, meaning it’s mechanism of action (technical jargon for “the way it works”) involves upmodulating acetylcholine production. Acetylcholine is a vital neurotransmitter involved in basic memory, learning and movement functions
Noopept is actually the trade name of the Russian pharmaceutical originally synthesized in 1996, N-phenylacetyl-L-prolyglycine ethyl ester. One of the benefits of Noopept over Piracetam is it’s potency. An average dose of Noopept is 10 to 30 mg as compared to 4+ grams of Piracetam. Like Piracetam, Noopept has neuroprotective properties in addition to it’s cognitive boosting effects, however the neuroprotective properties may only occur with those with some cognitive trauma. Only one human study has been done comparing Noopept and Piracetam but the findings suggest the only noticeable difference is dosage required. Noopept is generally classed together with the Racetam family but is not technically a Racetam due to it’s morpholine structure as opposed to the Pyrollidine backbone of the classic Racetams.
A Peek Under the Hood at Noopept's Mechanism of Action
Noopept seems to have a very short half-life in rat studies but as it is related to the endogenous amino acid polyglycine there may be active metabolites of noopept that also are responsible for some of its action. Noopept and piracetam are believed similar mechanism of action based on the fact that they result in similar EEG patterns. Both cause an increase in alpha waves, also called Berger’s waves in honor of the inventor of the Electric Encephalograph (EEG). This is brain state associated with a calm, creative state of mind. Like aniracetam it has an anxiolytic effect for some. Another thing to consider is that noopept may have reverse tolerance (less amounts required for desired effect) with use, a “snowballing” effect as it is sometimes called. Noopept may also have cholinosensitizing potential that could have a synergistic effect in use with other cholinergics like the Racetams.
Noopept as Anxiety Relief?
In addition to it’s cholinergic activity which can result in improved memory, recall and learning, noopept acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). The NDRI class of drugs can be useful not only for improving cognitive but can also be effective for those suffering from social anxiety, depression or mood disorder. Wellbutrin (Bupoprion) is a prescription medication whose mechanism of action is as an NDRI as well and has been prescribed for anxiety, depression and has even been useful in combating cigarette addiction.
With all racetams, if there is not enough choline (an essential “brain food”) in the diet some supplementation with choline bitartrate and citrate or higher quality choline sources like CDP choline and Alpha GPC may reduce symptoms of choline deficiency that can accompany heavy cholinergic usage without sufficient choline in the diet. Despite the relative safety of the classic nootropics, always remember to consult with a physician before undergoing any supplementation regimen especially if you’re already taking medications for any existing conditions
Because of Noopept’s low dosage requirements and mild taste it can be taken sublingually with great efficacy. As with most nootropics the best idea is to start low and titrate upwards as needed to avoid brain fog, headache or other negative side effects that could result from choline deficiency. Taking above 60mg a day could lead to overstimulation of glutamate receptors. Neurotransmitters either “excite" or “inhibit" neuronal activity. Glutamate is not only one of the most plentiful amino acids in the human body, but is also the primary excitatory neurotransmitter in mammal brains. Dangerous levels of excitotoxicity could be detrimental to overall functioning. Beginning around 5mg once or twice a day with a choline source or choline rich diet is a good idea. 10 - 30mg a day is a common dosage for noopept.
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